PPARα 、PPARγ 及 PPARδ 系列

Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARα has been localized to chromosome 22 (22q12-13.1).

Species   Gene Symbol     Gene Accession No.     Protein Accession No.
Human     PPARA                 NM_001001928          Q07869
Mouse      Ppara                    NM_011144              P23204
Rat           Ppara                    NM_013196              P37230

抑制剂

GW 6471

分子量:635.68     分子式:C35H36F3N3O5
Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:>98 %                10mg  ，50mg 规格
CAS No:[436159-64-7]          
Chemical Name:[(2S)-2-[[(1Z)-1-Methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propenyl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-carbamic acid ethyl ester

Sold with the permission of GlaxoSmithKline   过氧化物酶增殖活化受体α抑制剂 GW6471    PPARα 系列产品
PPARαantagonist that inhibits activation with an IC50 value of 0.24μM.

MK 886

分子量:472.08       分子式:C27H34ClNO2S
Solubility:Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:>98 %             10mg  ，50mg 规格
Storage:Store at RT
CAS No:[118414-82-7]
Chemical Name: 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic acid
别名：L-663,536
An inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Also moderately potent PPARαantagonist (IC50 = 0.5-1μM). Orally activein vivo.

激动剂

GW 7647
分子量:502.75              分子式：C29H46N2O3S
Solubility:Soluble to 25 mM in ethanol and to 100 mM in DMSO       
Purity:>99 %                 10mg  ，50mg 规格
CAS No:[265129-71-3]
Chemical Name: 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid
Potent and highly selective PPARαagonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγand PPARδreceptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubulesin vitro. Has lipid-lowering effects following oral administrationin vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties

Fenofibrate
分子量：360.83         分子式：C20H21ClO4
Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:>99 %              50mg 规格
Storage:Store at RT
CAS No:[49562-28-9]
Chemical Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.

Oleylethanolamide
分子量:325.53           分子式：C20H39NO2
Purity:>99 %              10mg  ，50mg 规格
Storage:Store at +4°C
CAS No:[111-58-0]
Chemical Name: (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide

Palmitoylethanolamide
分子量：299.5           分子式：C18N37NO2
Solubility:Soluble to 20 mM in DMSO and to 25 mM in ethanol
Storage:Store at RT       10mg  ，50mg 规格     
CAS No:[544-31-0]